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KMID : 0358619940280020151
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Korean Journal of Physiology
1994 Volume.28 No. 2 p.151 ~ p.157
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Calcium-activated Ionic Currents in Smooth Muscle Cells from Rabbit Superior Mesenteric Artery
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Lee Moo-Yeol
Bang Hyo-Weon
Uhm Dae-Yong
Rhee Sang-Don
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Abstract
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Intracellular free contributes to regulation of various events occurring in vascular smooth muscle cells. One of these events is modulating the membrane iou currents. Single smooth muscle cells were isolated from rabbit mesenteric artery. Three kinds of were studied with the patch clamp method. with a large oscillation was recorded in the depolarized potential range. The single channel conductance of this current was about 250 pS. It was abolished by replacing intracellular . A nonselective cation current was observed in both the depolarized and hyperpolarized potential ranges. And it was blocked by replacement of extracellular with N-methylglucamine (NMG) or extracellular application of . was revealed in the whole voltage range and was blocked by niflumic acid. These results indicate that at least three kinds of ionic currents exist in smooth muscle cells from rabbit superior mesenteric artery.
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KEYWORD
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Single smooth muscle cells, $Ca^{2+}-activated\, current$, patch clamp, Single channel recording
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